Biomarker-disease Associations
Which therapeutic areas are seeing the most research for the discovery, refinement or application of biomarkers? Which diseases are most frequently associated with the term "biomarker"?
To address these questions, we used PolySearch to extract and analyze relationships between the term "biomarker" and human diseases [1]. Below are the top 100 "text word: biomarker"-disease associations mined from PubMed. These data can be interpreted as a reflection of those therapeutic areas seeing a high degree of biomarker research and development.
The first column in this table gives the disease name; the second column gives the frequency of association (i.e. the number of citations indexed in PubMed that meet the query); the third column gives the total relevancy score (calculated from the R1, R2, R3 and R4 sentences) for the match term; the fourth column gives the Z-score (the number of standard deviations that the relevancy score is above the mean); the fifth column gives the database term's synonyms or aliases.
Frequency of association is not always the best way to determine relevancy. PolySearch employs a text ranking scheme to score the most relevant sentences and abstracts that associate both the query and match terms with each other. this is done by attempting to find query terms, association words and database terms to identify and calculate four relevancy sentences, termed R1, R2, R3 and R4, which are described below.
An R1 sentence contains one of the database terms, one of the query terms, at least one association word, and passes pattern recognition criteria. An R2 sentence contains one of the database terms, one of the query terms, and at least one association word. An R3 sentence contains one of the database terms and the query word. An R4 sentence contains just one of the database terms and is used for statistical normalization.
To generate a quantitative relevancy score, each relevancy sentence is assigned a value: R1 sentences are assigned a value of 50; R2 sentences are assigned a value of 25; R3 sentences are assigned a value of 5; and R4 sentences are assigned a value of 1. The sum of the R1, R2, R3 and R4 sentences is the relevancy score, which is then used to calculate a z-score (the number of standard deviations that the relevancy score is above the mean).
These data were generated on June 21st, 2011; Job ID: 1308337687.
References
- Cheng et al. PolySearch: a web-based text mining system for extracting relationships between human diseases, genes, mutations, drugs and metabolites. Nucleic Acids Res. 2008 Jul 1;36(Web Server issue):W399-405. Epub 2008 May 16.
| Disease Name | PubMed Hits | Relevancy Score | Z Score | Synonyms |
|---|
| breast cancer | 1025 (3,18,536,2890) | 28.4 | 6170 (3,18,536,2890) | Breast Cancer; Cancer of the Breast; Cancer of Breast; Malignant Breast Tumor; Malignant Neoplasm of the Breast; Malignant Tumor of the Breast; Malignant Neoplasm of Breast; Malignant Breast Neoplasm |
| prostate cancer | 754 (5,30,464,2327) | 5647 (5,30,464,2327) | 26 | Prostate Cancer; Cancer of the Prostate; Cancer of Prostate; Prostatic Cancer; Cancer, Prostate; Malignant Tumor of the Prostate; Cancer, Prostatic; Malignant Neoplasm of the Prostate |
| Ovarian cancer | 441 (5,12,308,1543) | 3633 (5,12,308,1543) | 16.7 | Ovarian Carcinoma; Ovarian Cancers; CARCINOMA OF OVARY; Ovary Cancer; Cancer of the Ovary; Cancer of Ovary; Ovarian Cancer; Ovary Cancers |
| lung cancers | 573 (2,8,285,1498) | 3223 (2,8,285,1498) | 14.8 | Malignant Tumor of the Lung; MALIGNANT LUNG NEOPLASM; Malignant tumor of lung; lung cancer; Cancer, Lung; Malignant Neoplasm of the Lung; Cancer of Lung; Cancer of the Lung |
| non small cell lung cancer | 366 (9,14,203,1199) | 3014 (9,14,203,1199) | 13.8 | Non Small Cell Carcinoma of Lung; Non Small Cell Lung Cancer; Non Small Cell Lung Carcinoma; non oat cell lung cancer; Non Small Cell Cancer of the Lung; Non Small Cell Lung Carcinomas; NSCLC Non small cell lung cancer; Non Small Cell Lung Carcinoma |
| colorectal cancer | 502 (0,4,216,1115) | 2295 (0,4,216,1115) | 10.5 | Cancer, Colorectal; Colorectal Cancer; Colorectal Cancers |
| chronic obstructive pulmonary disease | 156 (6,14,110,575) | 1775 (6,14,110,575) | 8 | CHRONIC OBSTRUCTIVE PULMONARY DISEASE; COPD; Chronic airway disease; Chronic obstructive pulmonary disease; COPD Chronic obstructive pulmonary disease; Chronic airflow limitation; Chronic Obstructive Airways Disease; Chronic Obstructive Lung Disease |
| gastric cancer | 210 (1,5,136,727) | 1582 (1,5,136,727) | 7.1 | gastric cancer; Stomach Cancers; Gastric cancer; Gastric Cancers; Malignant Neoplasm of the Stomach; Malignant neoplasm of stomach; Malignant Gastric Neoplasm; stomach cancer |
| dementia | 318 (5,10,86,558) | 1488 (5,10,86,558) | 6.7 | Dementia |
| bladder cancer | 193 (3,8,107,581) | 1466 (3,8,107,581) | 6.6 | Bladder Ca; Cancers, Bladder; Malignant Neoplasm of the Bladder; Bladder Cancer; Malignant tumor of urinary bladder; Malignant Neoplasm of Bladder; urinary bladder cancer; Cancer of bladder |
| atherosclerosis | 368 (1,7,115,615) | 1415 (1,7,115,615) | 6.4 | Atherosclerosis |
| heart failure | 329 (0,4,123,644) | 1359 (0,4,123,644) | 6.1 | Heart failure |
| Asthma | 206 (2,5,95,647) | 1347 (2,5,95,647) | 6.1 | Asthma |
| cardiovascular disease | 465 (1,2,130,594) | 1344 (1,2,130,594) | 6 | Circulatory disease; Cardiovascular system diseases; Cardiovascular disease; Circulatory Disorders; CIRCULATORY SYSTEM DISORDER; Diseases of the circulatory system; Disorder of the circulatory system; circulatory disorder |
| colon cancer | 308 (0,1,122,633) | 1268 (0,1,122,633) | 5.7 | Carcinoma of Colon; Colon Carcinoma; Colonic Carcinoma; CARCINOMA COLON; Carcinoma of the Colon; colorectal carcinogenesis; colon carcinogenesis; colon cancer |
| sepsis | 187 (0,3,115,547) | 1197 (0,3,115,547) | 5.4 | sepsis; Systemic infection; INFECTION SYSTEMIC |
| stroke | 238 (2,3,73,559) | 1099 (2,3,73,559) | 4.9 | Cerebral apoplexy; Apoplexy; Cerebrovascular Apoplexy; Cerebrovascular Accidents; Cerebral Stroke; Cerebral Strokes; Stroke, Cerebral; CVA cerebrovascular accident |
| pancreatic cancer | 171 (0,3,88,524) | 1039 (0,3,88,524) | 4.6 | Malignant Neoplasm of Pancreas; Malignant neoplasm of pancreas; Malignant Pancreatic Neoplasm; Pancreas Cancers; Pancreatic Cancers; Cancer of pancreas; Malignant tumor of pancreas; Pancreatic Cancer |
| multiple sclerosis | 184 (3,9,58,343) | 1008 (3,9,58,343) | 4.5 | Multiple Sclerosis; MS Multiple sclerosis; Sclerosis, Disseminated; disseminated sclerosis; insular sclerosis; SCLEROSIS, MULTIPLE; DS Disseminated sclerosis; SCLEROSIS MULTIPLE |
| rheumatoid arthritis | 180 (4,6,57,280) | 915 (4,6,57,280) | 4.1 | RA Rheumatoid arthritis; Atrophic Arthritis; Rheumatoid Arthritis; Chronic rheumatic arthritis; Rheumatic gout; ARTHRITIS, RHEUMATOID; ARTHRITIS, RHEUMATIC; Rheumatoid disease |
| hepatocellular carcinoma | 305 (0,1,69,483) | 853 (0,1,69,483) | 3.8 | Hepatocellular cancer; Hepatocellular carcinoma |
| cervical cancer | 149 (1,2,77,354) | 839 (1,2,77,354) | 3.7 | Malignant Tumor of the Cervix; Ca cervix; cervix cancer; Malignant Neoplasm of the Cervix; Uterine Cervical Cancers; cervical cancer; Malignant Neoplasm of the Uterine Cervix; Malignant Cervical Tumor |
| schizophrenia | 129 (1,2,63,400) | 815 (1,2,63,400) | 3.6 | SCHIZOPHRENIA; Schizophrenic Disorder; Schizophrenias; Dementia Praecox; Schizophrenic Disorders |
| cancer progression | 299 (0,5,66,357) | 812 (0,5,66,357) | 3.6 | cancer progression; tumor progression; neoplastic progression; Cancer Progression; neoplasm progression |
| osteoarthritis | 145 (2,8,56,224) | 804 (2,8,56,224) | 3.5 | Osteoarthritis |
| melanoma | 127 (2,3,52,349) | 784 (2,3,52,349) | 3.4 | Melanoma; Melanoepithelioma; Melanoblastoma |
| metabolic syndrome | 149 (1,2,65,318) | 743 (1,2,65,318) | 3.3 | Metabolic syndrome; metabolic syndrome |
| coronary artery disease | 254 (1,3,53,329) | 719 (1,3,53,329) | 3.1 | Coronary arteriosclerosis; Cad; Arteriosclerotic heart disease; Atherosclerosis, Coronary; Atherosclerotic heart disease; Coronary Atherosclerosis; CORONARY SCLEROSIS; Ischaemic heart disease |
| fibrosis | 156 (1,2,55,323) | 698 (1,2,55,323) | 3 | Fibrosis |
| neoplasia | 184 (0,4,67,259) | 694 (0,4,67,259) | 3 | New growth; Neoplastic growth; neoplasia; NEOPLASMS OF UNSPECIFIED NATURE; Tumour NOS; Neoplastic syndrome; Tumor NOS; Neoplastic disease |
| hypertension | 254 (0,0,55,409) | 684 (0,0,55,409) | 3 | High Blood Pressures; HTN; hyperpiesis; HBP High blood pressure; vascular hypertension; Blood Pressure, High; Hyperpiesia; Hypertensive diseases |
| tumorigenesis | 241 (0,4,48,301) | 641 (0,4,48,301) | 2.8 | tumorigenesis; oncogenesis; Tumorigenesis |
| genotoxicity | 176 (0,0,71,281) | 636 (0,0,71,281) | 2.8 | genotoxicity |
| renal cell carcinoma | 154 (0,3,49,296) | 616 (0,3,49,296) | 2.7 | RENAL CELL CARCINOMA; Renal Cell Adenocarcinomas; Hypernephroma; Adenocarcinoma, Renal Cell; Renal Cell Cancer; renal cell adenocarcinoma; Adenocarcinoma of Kidney; Carcinoma, Renal Cell |
| renal disease | 173 (1,2,53,242) | 607 (1,2,53,242) | 2.6 | Kidney diseases; Disease, Kidney; Renal Disorder; Diseases, Kidney; Kidney disease; Renal disease; kidney disorder; Kidney Disorders |
| neurodegenerative diseases | 193 (1,3,43,229) | 569 (1,3,43,229) | 2.5 | Neurologic Degenerative Disease; Degenerative Neurologic Disorder; Neurodegenerative Disorder; Neurodegenerative Disorders; Degenerative Neurologic Disorders; Degenerative Neurologic Diseases; Degenerative Neurologic Disease |
| non alcoholic fatty liver | 49 (3,11,12,73) | 558 (3,11,12,73) | 2.4 | Non alcoholic fatty liver; Nonalcoholic fatty liver |
| squamous cell carcinoma | 223 (0,0,39,320) | 515 (0,0,39,320) | 2.2 | Squamous Cell Carcinoma |
| hypoxia | 149 (0,0,39,316) | 511 (0,0,39,316) | 2.2 | oxygen deficiency; Hypoxia; Oxygen Deficiencies; Oxygen Deficiency; Hypoxias; Decreased oxygen supply |
| dysplasia | 154 (0,1,37,299) | 509 (0,1,37,299) | 2.2 | dysplasia; Dyscrasia; dyscrasic; Freeman Sheldon Syndrome; Craniocarpotarsal dystrophy; FSS |
| acute coronary syndrome | 162 (0,1,44,247) | 492 (0,1,44,247) | 2.1 | Acute coronary syndrome |
| endometrial cancer | 96 (0,0,42,280) | 490 (0,0,42,280) | 2.1 | Endometrial Ca; carcinoma of the endometrium; Cancer of Endometrium; CARCINOMA OF ENDOMETRIUM; ENDOMETRIAL CARCINOMA; Endometrium Cancers; Endometrial Cancer; Endometrium Carcinomas |
| systemic lupus erythematosus | 97 (2,5,20,149) | 474 (2,5,20,149) | 2 | LE SYNDROME; LUPUS SYNDROME; Systemic lupus erythematosus; LUPUS ERYTHEMATOSUS, DISSEMINATED; SLE Systemic lupus erythematosus; Disseminated lupus erythematosus; LUPUS ERYTHEMATOSUS SYSTEMIC; Lupus Erythematosus Disseminatus |
| autoimmune diseases | 110 (2,3,29,153) | 473 (2,3,29,153) | 2 | autoimmune disease; Diseases, Autoimmune; AUTOIMMUNE DISORDER; Autoimmune Disorders; Disease, Autoimmune; Autoimmune Disease; Autoimmune diseases |
| neurodegeneration | 127 (1,4,32,156) | 466 (1,4,32,156) | 2 | neural degeneration; Nerve Degeneration; Neuron Degenerations; Neuron Degeneration; Nerve Degenerations; neurodegeneration |
| arthritis | 71 (2,4,26,133) | 463 (2,4,26,133) | 2 | Arthritis; arthritic |
| preeclampsia | 70 (0,1,36,250) | 455 (0,1,36,250) | 1.9 | EPH Complex; Pre Eclampsia; EPH Gestosis; Proteinuric hypertension of pregnancy; Toxemia of pregnancy; EPH Toxemia; PET Pre eclamptic toxaemia; Pre Eclampsia |
| liver disease | 105 (1,5,22,149) | 434 (1,5,22,149) | 1.8 | hepatic disorder; Liver disease; Disorder of liver; Diseases, Liver; HEPATIC: HEPATOCELLULAR; Liver diseases; DISEASE HEPATOCELLULAR; HEPATIC DISORDER |
| Alzheimer type dementia | 140 (0,1,37,219) | 429 (0,1,37,219) | 1.8 | AD Alzheimer's disease; Dementia, Senile; Senile Dementia; SDAT; Alzheimer Disease; DEMENTIA OF THE ALZHEIMER TYPE; Alzheimer Type Dementia; Alzheimer's Disease |
| psoriasis | 34 (2,5,19,99) | 419 (2,5,19,99) | 1.8 | psoriasis; Psoriases |
| lupus nephritis | 36 (3,4,18,73) | 413 (3,4,18,73) | 1.7 | Lupus nephritis; Lupus Glomerulonephritis; Lupus Nephritis; Lupus Nephritides |
| Cardiovascular diseases | 155 (0,1,42,178) | 413 (0,1,42,178) | 1.7 | Cardiovascular Diseases; CVS disease; Cardiovascular Disorder; Disease, Cardiovascular; Diseases, Cardiovascular; Cardiovascular system disease; Cardiovascular Disorders; DISORDER CARDIOVASCULAR |
| liver fibrosis | 65 (0,3,32,158) | 393 (0,3,32,158) | 1.6 | FIBROSIS LIVER; Liver Fibroses; Fibrosis of liver; Fibrosis, Liver; Liver Fibrosis; HEPATIC FIBROSIS |
| breast tumors | 140 (0,0,33,205) | 370 (0,0,33,205) | 1.5 | breast neoplasm; Breast tumour; Neoplasm of breast; Breast Neoplasm; Tumors, Breast; Breast Tumor; Tumor of the Breast; Tumor, Breast |
| cirrhosis | 110 (0,0,26,238) | 368 (0,0,26,238) | 1.5 | Cirrhosis |
| metastatic tumor | 197 (0,2,22,200) | 360 (0,2,22,200) | 1.5 | Secondary Neoplasm; METS; Secondary Cancer; metastatic disease; Metastatic Neoplasm; Metastasize; Secondary Tumor; Secondary malignant deposit |
| ischemic stroke | 74 (1,1,24,161) | 356 (1,1,24,161) | 1.5 | Ischemic stroke |
| colorectal carcinoma | 89 (1,1,25,150) | 350 (1,1,25,150) | 1.4 | Colorectal Carcinoma; Cancer of large intestine; Cancer of the Large Intestine; Colorectal Carcinomas; Carcinoma of the Large Bowel; Large Intestine Cancer; Carcinoma of the Large Intestine; Large Intestine Carcinoma |
| glioblastoma | 63 (1,1,22,155) | 340 (1,1,22,155) | 1.4 | Glioblastoma; Mouse Glioblastoma |
| chronic kidney disease | 124 (0,0,31,181) | 336 (0,0,31,181) | 1.4 | Chronic kidney disease |
| oral cancers | 70 (0,0,32,168) | 328 (0,0,32,168) | 1.3 | Cancer of Mouth; Mouth Cancer; Cancer of oral cavity; Mouth Cancers; Malignant Tumor of the Mouth; Malignant Mouth Neoplasm; Oral Cancers; oral cancer |
| glioma | 91 (0,0,26,197) | 327 (0,0,26,197) | 1.3 | Glioma |
| vascular disease | 86 (1,1,28,102) | 317 (1,1,28,102) | 1.3 | Disease, Vascular; Vascular Diseases; blood vessel disorder; Vascular Disorder; Vascular Disorders; Vascular disease; DISORDER VASCULAR; VASCULAR PROBLEM |
| autism | 48 (0,1,29,145) | 315 (0,1,29,145) | 1.3 | Autistic thinking; Autism |
| acute respiratory distress syndrome | 59 (0,0,32,154) | 314 (0,0,32,154) | 1.3 | SHOCK LUNG; Acute Respiratory Distress Syndrome; adult respiratory distress syndrome; Adult RDS; Pulmonary capillary leak syndrome; Human ARDS; WET LUNG SYNDROME; ARDS Adult respiratory distress syndrome |
| cellular proliferation | 134 (1,1,14,168) | 313 (1,1,14,168) | 1.3 | HYPERPLASIA; Hyperplastic; Hyperplasias; Hypercellularity; Cellular proliferation |
| Barrett's esophagus | 71 (0,0,26,182) | 312 (0,0,26,182) | 1.3 | Barretts esophagus; CLE; Columnar Epithelial Lined Lower Esophagus; Esophagus, Barrett's; CELLO; BE; Columnar Lined Esophagus; Barrett's Esophagus |
| human immunodeficiency virus | 76 (0,3,22,124) | 309 (0,3,22,124) | 1.2 | acquired immunodeficiency syndrome; Acquired immune deficiency syndrome; HIV; Immunodeficiency Syndrome, Acquired; AIDS Acquired immunodeficiency syndrome; Acquired Immuno Deficiency Syndrome; AIDS; Human Immunodeficiency Virus |
| adenocarcinomas | 154 (0,0,18,213) | 303 (0,0,18,213) | 1.2 | Adenocarcinoma; Malignant Adenomas; ADENOCARCINOMA NOS; Malignant Adenoma; Adenocarcinomas |
| chromosomal abnormality | 130 (0,0,25,173) | 298 (0,0,25,173) | 1.2 | Chromosomal Aberration; Chromosomal Aberrations; Chromosome abnormalities; Chromosome Abnormality; Chromosome Anomalies; Cytogenetic Abnormality; chromosome aberration; Chromosomal Abnormalities |
| tuberculosis | 55 (0,1,25,139) | 289 (0,1,25,139) | 1.2 | tuberculosis; Tuberculoses; INFECTION TUBERCULOSIS; Mycobacterium tuberculosis infection; TB Tuberculosis; Infection due to Mycobacterium tuberculosis; TB |
| squamous cell carcinomas | 147 (0,0,18,195) | 285 (0,0,18,195) | 1.1 | Squamous Carcinoma; epidermoid carcinoma; Carcinomas, Squamous Cell; Carcinomas, Squamous; Squamous Cell Epithelioma; CARCINOMA EPIDERMOID; Carcinoma, Epidermoid; Squamous Cell Carcinomas |
| esophageal cancer | 78 (0,0,23,161) | 276 (0,0,23,161) | 1.1 | Cancer of esophagus; Esophagus Cancers; Malignant Tumor of the Esophagus; Esophageal Cancers; esophagus cancer; Malignant Neoplasm of Esophagus; Malignant Neoplasm of the Esophagus; Cancer of the Esophagus |
| inflammatory bowel disease | 44 (1,3,17,64) | 274 (1,3,17,64) | 1.1 | Inflammatory Bowel Disease |
| psychiatric disorders | 59 (1,2,16,83) | 263 (1,2,16,83) | 1 | mental disorder; psychological disorder; Mental disorder; Psychiatric Disorders; Unspecified Mental Disorder; Disorders, Mental; Mental health disorder; Psychiatric illness |
| end stage renal disease | 75 (0,0,20,163) | 263 (0,0,20,163) | 1 | End Stage Renal Disease; ESRD; Renal Failure, End Stage; ESRF End stage renal failure; End stage renal failure; Renal Failure, End Stage; End Stage Kidney Disease; Disease, End Stage Renal |
| Lewy body Parkinson's disease | 52 (1,2,18,71) | 261 (1,2,18,71) | 1 | Parkinson's disease; Idiopathic parkinsonism; PARKINSON'S SYNDROME; Paralysis Agitans; Primary Parkinsonism; Lewy Body Parkinson's Disease; PD Parkinson's disease; Shaking Palsy |
| lymphoma | 73 (0,1,25,111) | 261 (0,1,25,111) | 1 | Reticulolymphosarcomas; Malignant lymphoma; Lymphomas; lymphoma; Germinoblastoma; LYMPHOMA MALIGNANT; Malignant Lymphomas; Germinoblastic Sarcoma |
| breast carcinoma | 97 (0,1,21,129) | 259 (0,1,21,129) | 1 | BREAST CARCINOMA; Carcinoma of the Breast; Breast Carcinoma; CARCINOMA OF BREAST; Cancer of the Breast; CARCINOMA BREAST; Mammary Carcinoma; Cancer of Breast |
| myocardial ischemia | 78 (0,0,30,108) | 258 (0,0,30,108) | 1 | Heart Diseases, Ischemic; Ischaemic heart disease; Ischemic heart disease; IHD Ischemic heart disease; myocardial ischemia; myocardial ischemia/hypoxia; Cardiac ischemia; Disease, Ischemic Heart |
| adenomas | 99 (0,1,12,172) | 257 (0,1,12,172) | 1 | Adenomas |
| cystic fibrosis | 55 (1,1,17,94) | 254 (1,1,17,94) | 1 | Cystic Fibrosis; CF; Mucoviscidosis; Fibrosis, Cystic; CF Cystic fibrosis; Fibrocystic disease; Mucosis |
| neuromyelitis optica | 45 (0,2,20,103) | 253 (0,2,20,103) | 1 | Devic Disease; Devic syndrome; DEVIC DISEASE; Devic's Syndrome; NEUROMYELITIS OPTICA; OPHTHALMONEUROMYELITIS; Optic neuromyelitis |
| Osteoporosis | 59 (0,1,20,127) | 252 (0,1,20,127) | 1 | OSTEOPOROSIS |
| glial tumors | 57 (1,1,15,100) | 250 (1,1,15,100) | 1 | Glial Cell Tumors; Glial Tumor; glial tumors; Neuroglial Tumor; Gliomas; Glial Neoplasm; Glioma NOS; Neuroglial Neoplasms |
| ovarian tumors | 87 (0,0,20,150) | 250 (0,0,20,150) | 1 | Tumor of the Ovary; Ovarian Neoplasm; Tumour of ovary; Neoplasm of the Ovary; Ovarian Tumors; OVARIAN NEOPLASIA; Ovarian tumour; Ovarian Neoplasms |
| pancreatic ductal adenocarcinoma | 43 (1,3,10,69) | 244 (1,3,10,69) | 0.9 | Pancreatic Ductal Adenocarcinoma; Ductal Adenocarcinoma of the Pancreas; Pancreas Ductal Adenocarcinoma |
| lung disease | 86 (0,1,20,115) | 240 (0,1,20,115) | 0.9 | Pulmonary Disorders; Pulmonary Diseases; Disease, Pulmonary; PULMONARY DISORDERS; Lung Disorder; Lung Disease; Lung Disorders; PULMONARY DISORDER |
| septic shock | 49 (0,1,17,128) | 238 (0,1,17,128) | 0.9 | Septicemic shock; Septic shock; Sepsis associated hypotension; Septicaemic shock; Shock, Septic |
| ductal carcinoma in situ | 47 (0,0,18,144) | 234 (0,0,18,144) | 0.9 | Non infiltrating intraductal carcinoma; DCIS of the breast; Noninfiltrating Intraductal Carcinoma; Non Infiltrating Intraductal Carcinoma; DCIS; Ductal Carcinoma in situ of the Breast; Intraductal carcinoma; in situ ductal breast carcinoma |
| head and neck squamous cell carcinoma | 88 (0,1,18,118) | 233 (0,1,18,118) | 0.9 | Head and Neck Carcinoma; Carcinoma of Head and Neck; Head and Neck Squamous Cell Carcinoma |
| Periodontitis | 47 (0,1,13,142) | 232 (0,1,13,142) | 0.9 | Periodontitis; Chronic periodontitis; Periodontitides; Chronic pericementitis; PERIODONTITIS |
| esophageal squamous cell carcinoma | 75 (0,0,21,127) | 232 (0,0,21,127) | 0.9 | SCC of the Esophagus; Squamous Cell Carcinoma of the Esophagus; Squamous cell carcinoma of oesophagus; Squamous Cell Carcinoma of Esophagus; Esophageal Squamous Cell Carcinoma; Esophageal Epidermoid Carcinoma; squamous cell esophageal cancer |
| diffuse large B cell lymphoma | 35 (0,0,24,111) | 231 (0,0,24,111) | 0.9 | DLBCL; Diffuse large B cell lymphoma |
| head and neck cancer | 92 (0,0,21,126) | 231 (0,0,21,126) | 0.9 | head and neck cancer; Malignant Head and Neck Neoplasm; Cancer of Head and Neck; Malignant tumor of head and neck; Malignant Neoplasm of the Head and Neck; Head and Neck Cancer; Malignant Tumor of the Head and Neck; Malignant Head and Neck Tumor |
| pneumonitis | 38 (1,2,15,53) | 228 (1,2,15,53) | 0.9 | Pneumonitis; PNEUMONITIS; Lung Inflammations; Inflammation, Lung; Lung Inflammation; Pulmonary Inflammation; Pneumonias; Pneumonitides |
| liver cancer | 94 (0,0,20,128) | 228 (0,0,20,128) | 0.9 | Cancer of Liver; Hepatic Cancers; Cancer of the Liver; Liver Cancer; Hepatic Cancer; Malignant tumor of liver; Malignant tumour of liver; Cancer, Liver |
| mesothelioma | 25 (1,1,16,70) | 225 (1,1,16,70) | 0.9 | Mesothelioma |
| neurological disorders | 83 (0,1,21,94) | 224 (0,1,21,94) | 0.9 | Neurological disorders; Neurologic Disorder; Neurological Disorders; Neurologic Disorders; Disorders, Nervous System; neurological disease; Nervous system disease; Diseases, Nervous System |
| brain tumors | 66 (0,0,22,112) | 222 (0,0,22,112) | 0.8 | Brain tumor; BRAIN NEOPLASM; Neoplasm of brain; Brain tumour; Tumor, Brain; brain tumor; Neoplasm of the Brain; Brain Neoplasms |
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